100 Management Essentials: USMLE Step 2 CK

Mastering the "Next Best Step" for Clinical Excellence.

Case #1Cardiology
A 65-year-old male with sudden "tearing" back pain. BP is 190/110 in the right arm and 140/80 in the left arm.
What is the next best step in management?

Next Step: IV Beta-blockers (Labetalol)

Rationale: Stanford Type B dissection requires heart rate and BP control. Type A requires surgical consultation. Goal is HR < 60 and SBP 100-120.

Case #2Trauma
Trauma patient with tracheal deviation, absent breath sounds on the right, and hypotension (BP 80/40).
What is the next best step?

Next Step: Needle Decompression

Rationale: Clinical diagnosis of Tension Pneumothorax. Do NOT wait for a CXR. Follow with chest tube (tube thoracostomy).

Case #3OBGYN
A 24-year-old female with RLQ pain and vaginal spotting. Beta-hCG is 3000. Ultrasound shows empty uterus and a complex right adnexal mass. Patient is stable.
Next best step?

Next Step: Methotrexate or Laparoscopy

Rationale: If stable and mass < 4cm, Methotrexate is an option. If unstable (hypotension), immediate surgery (Laparotomy/Laparoscopy).

Case #4Respiratory
Post-op patient with sudden dyspnea and pleuritic chest pain. Well's score is high (6).
Next best step?

Next Step: CT Angiography (CTPA)

Rationale: In a stable patient with high suspicion, CTPA is the gold standard. If CT is contraindicated (renal failure), perform V/Q scan.

Case #5Pediatrics
3-year-old unimmunized child with high fever, drooling, and tripod positioning.
Next best step?

Next Step: Endotracheal Intubation in OR

Rationale: Secure the airway immediately. Do not examine the throat in the ED as it may trigger laryngospasm.

Case #6Endocrine/Renal
Patient with missed dialysis. K+ is 7.2. ECG shows peaked T-waves and widened QRS.
Immediate next step?

Next Step: IV Calcium Gluconate

Rationale: Stabilize the cardiac membrane first. Then follow with Insulin/Glucose and Albuterol to shift K+ intracellularly.

Case #7Surgery
Fat, female, forty. RUQ pain and positive Murphy sign. Ultrasound is inconclusive but shows gallstones.
Next best step?

Next Step: HIDA Scan

Rationale: HIDA is the most sensitive test if Ultrasound is equivocal for cholecystitis.

Case #8Neurology
Sudden right-sided weakness that started 2 hours ago.
Next best step?

Next Step: Non-contrast CT Head

Rationale: Rule out hemorrhage before considering thrombolytics (tPA).

Case #9Psychiatry
Patient on Haloperidol presents with "lead-pipe" rigidity, high fever, and elevated CK levels.
Next best step?

Next Step: Discontinue Neuroleptic & Supportive Care

Rationale: Stop the offending agent. Dantrolene or Bromocriptine can be used in severe cases.

Case #10Endocrine
Hyperthyroid patient with fever, tachycardia (140s), and agitation after surgery.
Next best step?

Next Step: Propranolol, PTU, Iodine, Glucocorticoids

Rationale: The order matters: Propranolol first (symptoms), then PTU (block synthesis), then Iodine (block release—must be 1 hour after PTU).

Additional 90 High Yield Management Steps Included in Syllabus:

  • 11. Septic Shock: Early aggressive fluid resuscitation (30ml/kg).
  • 12. Status Epilepticus: IV Lorazepam, then Fosphenytoin.
  • 13. GI Bleed: Two large-bore IVs, IV PPI, and Octreotide (if variceal).
  • 14. Preeclampsia w/ Severe Features: Magnesium Sulfate + Delivery.
  • 15. Meningitis: Vancomycin + Ceftriaxone + Dexamethasone (before or with first dose).
  • 16. Hip Fracture: Surgical fixation within 24-48 hours.
  • 17. Appendicitis: Clinical diagnosis; CT if uncertain; then surgery.
  • 18. TIA: Carotid Doppler and Echocardiogram.
  • 19. CHF Exacerbation: LasiX (Furosemide), Morphine, Nitrates, Oxygen (LMNOP).
  • 20. COPD Flare: Bronchodilators, Corticoids, Antibiotics, Oxygen (88-92%).
  • 21. Asthma Acute: Albuterol + Ipratropium + Systemic Steroids.
  • 22. Gout Acute: NSAIDs (Indomethacin) or Colchicine.
  • 23. Cellulitis: Cephalexin or Clindamycin.
  • 24. Pyelonephritis: Ciprofloxacin (outpatient) or IV Ceftriaxone (inpatient).
  • 25. Nephrolithiasis: Fluids, Analgesia, Tamsulosin (for stone passage).
  • 26. BPH: Alpha-blockers (Tamsulosin) followed by 5-alpha reductase inhibitors.
  • 27. Prostate CA: Biopsy if PSA is high or DRE is abnormal.
  • 28. Breast Mass: <30 (US), >30 (Mammogram), then Biopsy.
  • 29. Cervical CA: LEEP or Cone biopsy if high-grade dysplasia.
  • 30. Endometrial CA: Postmenopausal bleeding = Endometrial Biopsy.
  • 31. Ovarian Torsion: Urgent Detorsion via Laparoscopy.
  • 32. PID: Ceftriaxone (IM) + Doxycycline (Oral).
  • 33. Syphilis: Penicillin G (benzathine).
  • 34. HIV Exposure: PEP within 72 hours (Tenofovir/Emtricitabine/Raltegravir).
  • 35. Iron Deficiency: Oral Ferrous Sulfate.
  • 36. Sickle Cell Pain: Hydration, Oxygen, Morphine.
  • 37. Multiple Myeloma: Bone Marrow Biopsy (>10% plasma cells).
  • 38. Lymphoma: Excisional Lymph Node Biopsy (NOT needle biopsy).
  • 39. TTP: Plasmapheresis (Plasma Exchange).
  • 40. Major Depression: SSRIs + Psychotherapy.
  • ... [See our Premium PDF for cases 41 to 100]